John Guatelli, MD
Professor of Medicine
University of California San Diego School of Medicine
Staff Physician
San Diego Veteran Affairs Healthcare System
La Jolla, CA

Research Topics

• Molecular virology of HIV-1
• HIV-1 Vpu protein
• HIV-1 Nef protein

Lecture and Writing Topics

• Molecular virology of the HIV-1 accessory proteins Vpu and Nef
• Pathogenesis of HIV-1
• Host-pathogen interactions during HIV replication emphasizing evasion of innate and adaptive immunity

Current Professional Summary

Dr Guatelli is Professor of Medicine at the University of California San Diego, where he teaches medical microbiology. Dr Guatelli is trained in infectious diseases medicine and has an HIV primary care clinic within the San Diego Veterans Affairs Healthcare System. His primary activity is basic research on the host-pathogen interactions mediated by the HIV-1 proteins Vpu and Nef, specifically how these allow the virus to evade the innate and adaptive immune responses.

Committees and Organizations

• Member, AIDS Molecular and Cellular Biology Study Section, National Institute of Allergy and Infectious Disease, National Institutes of Health
• Member, American Society for Microbiology

Honors and Awards

• Phi Beta Kappa

Education

• University of Colorado, BA (1978)
• University of California, MD (1980)

Selected Publications

1. Noviello CM, Benichou S, Guatelli JC. Cooperative binding of the class I major histocompatibility complex cytoplasmic domain and human immunodeficiency virus type 1 Nef to the endosomal AP-1 complex via its mu subunit. J Virol. 2008;82:1249-1258.
2. Van Damme N, Goff D, Katsura C, Jorgenson RL, Mitchell R, Johnson MC, et al. The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein. Cell Host Microbe. 2008;3:245-252.
3. Mitchell RS, Katsura C, Skasko MA, Fitzpatrick K, Lau D, Ruiz A, et al. Vpu antagonizes BST-2-mediated restriction of HIV-1 release via beta-TrCP and endo-lysosomal trafficking. PLoS Pathog. 2009;5:e1000450.
4. Fitzpatrick K, Skasko M, Deerinck TJ, Crum J, Ellisman MH, Guatelli J. Direct restriction of virus release and incorporation of the interferon-induced protein BST-2 into HIV-1 particles. PLoS Pathog. 2010;6:e1000701.
5. Guatelli J. How innate immunity can inhibit the release of HIV-1 from infected cells. N Engl J Med. 2010;362:553-554.
6. Evans DT, Serra-Moreno R, Singh RK, Guatelli JC. BST-2/tetherin: a new component of the innate immune response to enveloped viruses. Trends Microbiol. In press.

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