Physician Education: Bridging Clinical Research and Patient Care

Faculty Profile

Senior Investigator
National Institute of Allergy and Infectious Diseases
National Institutes of Health
Laboratory of Immunoregulation
Bethesda, MD

Topics of Professional Interest:
  • Opportunistic infections
  • Immune reconstitution
  • Antiretroviral therapy
  • Treatment interruptions
  • Emergency care of HIV-infected persons
  • HIV viral kinetics
Current Professional Summary:

Dr Polis is a Senior Investigator with the Intramural AIDS Program, Laboratory of Immunoregulation, National Institute of Allergy and Infectioius Diseases. He is a senior consultant for the Infectious Diseases Consultation Service, as well as a Clinical Professor of Emergency Medicine at George Washington University Medical Center.

Committees and Organizations:
  • Vice Chair, Chair, NIAID Institutional Review Board (1994–1996)
  • USPHS/IDSA Prevention of Opportunistic Infections Working Group (1994–)
  • Panel on Treatment of Cytomegalovirus Diseases in Persons with AIDS,
    IAS–USA (1997)
  • Practice Guidelines Committee, Infectious Diseases Society of America (1998–1999)
  • Chair, NIH Pharmacy and Therapeutics Committee (1998–)
  • Yale University, BS Chemistry (1976)
  • Albert Einstein College of Medicine, MD (1980)
  • George Washington University Medical Center, Residency, Internal Medicine/Primary Care (1980–1983)
  • The Johns Hopkins University School of Hygiene and Public Health, MPH (1986)
  • National Institute of Allergy and Infectious Diseases, USPHS Epidemiology Training Program (1985–1988)
Selected Publications:
  1. Kovacs JA, Kovacs AA, Polis M, Wright WC, Gill VJ, Tuazon CU, Gelmann EP, Lane HC, Longfield R, Overturf G, Macher AM, Fauci AS, Parillo JE, Bennett JE, Masur H. Cryptococcus in the acquired immunodeficiency syndrome. Ann Intern Med. 1985;103:533-539.
  2. Palestine AG, Polis MA, DeSmet MD, Baird BF, Falloon J, Kovacs JA, Davey RT, Zurlo JJ, Zunich KM, Davis M, Hubbard L, Brothers R, Ferris FL, Chew E, Davis JL, Rubin BL, Mellow S, Metcalf J, Manischewitz J, Minor J, Nussenblatt RB, Masur H, Lane HC. A randomized, controlled trial of foscarnet in the treatment of cytomegalovirus retinitis in patients with AIDS. Ann Intern Med. 1991;115:665-673.
  3. Polis MA, De Smet MD, Baird BF, Mellow SD, Falloon J, Davey RT Jr, Kovacs JA, Palestine AG, Nussenblatt RB, Masur H, Lane HC. Increased survival of a cohort of patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis who received sodium phosphonoformate (foscarnet). Am J Med. 1993;94:175-180.
  4. Zurlo JJ, Wood L, Gaglione M, Polis MA. Effect of splenectomy on T-lymphocyte subsets in splenectomized, HIV-infected patients. Clin Infect Dis. 1995;20:768-771.
  5. Polis MA, Spooner KM, Baird BF, Manischewitz JF, Jaffe HS, Fisher PE, Falloon J, Davey RT Jr, Kovacs JA, Walker RE, Whitcup SM, Nussenblatt RB, Lane HC, Masur H. Anticytomegaloviral activity and safety of cidofovir in patients with HIV infection and cytomegalovirus viruria. Antimicrob Agents Chemother. 1995;39:882-886.
  6. Polis MA, Piscitelli SC, Vogel S, Witebsky FG, Conville PS, Petty B, Kovacs JA, Davey RT Jr, Walker RE, Falloon J, Metcalf JA, Craft C, Lane HC, Masur H. Clarithromycin lowers plasma zidovudine levels in persons with HIV infection. Antimicrob Agents Chemother. 1997;41:1709-1714.
  7. Orenstein JM, Feinberg M, Yoder C, Schrager L, Mican J, Schwartzentruber DJ, Davey RT Jr, Walker RE, Falloon J, Kovacs JA, Fox C, Metcalf J, Masur H, Polis MA. Lymph node architecture preceding and following potent antiviral therapy: follicular hyperplasia persists in parallel with p24 antigen. Cellular repopulation after lymph node involution and CD4 cell depletion in an AIDS patient. AIDS. 1999;13:2219-2220.
  8. Grossman Z, Polis M, Feinberg MB, Grossman Z, Levi, Jankelevich S, Yarchoan R, Boon J, de Wolf F, Lange JMA, Goudsmit J, Dimitrov DS, Paul WE. Ongoing HIV dissemination under HAART. Nat Med. 1999;10:1099-1104.
  9. Whitcup SM, Fortin E, Lindblad AS, Baird B, Perry C, Metcalf JA, Manischewitz J, Griffiths P, Kidd IM, Masur H, Nussenblatt RB, Robinson M, Davey RT Jr, Falloon J, Walker RE, Kovacs JA, Vrabec T, Lane HC, Smith J, Polis MA. Successful discontinuation of specific anticytomegalovirus therapy in persons with HIV infection and cytomegalovirus retinitis: results of a longitudinal intervention trial. JAMA. 1999;282:1633-1668.
  10. Hatano H, Vogel S, Yoder C, Metcalf JA, Dewar R, Davey RT Jr, Polis MA. Pre-HAART HIV burden approximates post-HAART viral levels following interruption of therapy in patients with sustained viral suppression. AIDS. 2000;14:1357-1363.