Physician Education: Bridging Clinical Research and Patient Care

Faculty Profile

Division of Infectious Diseases
Advanced Clinical Research Center
Institute of Medical Science
University of Tokyo
Tokyo, Japan

Topics of Professional Interest:
  • HIV pathogenesis
  • HIV-specific immune responses
  • Therapeutic vaccines
  • Opportunistic infections
  • Basic science research in HIV
  • Antiretroviral therapy
Current Professional Summary:

Dr Iwamoto is a professor at the University of Tokyo, where he has conducted basic research on HIV/AIDS since 1994 in the Division of Infectious Diseases of the Institute of Medical Science. He also oversees the HIV clinic in the Institute of Medical Science Research Hospital. Dr Iwamoto's research interests include a wide range of both basic and clinical aspects in HIV medicine, such as HIV pathogenesis, host immune responses against HIV, therapeutic vaccines, host genetic factors, and opportunistic infections.

Committees and Organizations:
  • Member, Editorial Advisory Board, Journal of Infectious Diseases, 2003-
  • Editor, Japanese Association for Infectious Diseases, 2001-
  • Editor, Japanese Society for Virology, 2001-
  • Committee for Infectious Diseases, Japan Ministry of Health, Labor, and Welfare, 1999-
  • Committee for Blood Safety, Japan Ministry of Health, Labor, and Welfare, 2000-
  • Faculty of Medicine, University of Tokyo, MD (1974)
  • University of Tokyo, Doctor of Medical Science (1984)
Selected Publications:
  1. Shioda T, Kato H, Ohnishi Y, Tashiro K, Ikegawa M, Nakayama EE, Hu H, Kato A, Sakai Y, Liu H, Honjo T, Nomoto A, Iwamoto A, Morimoto C, Nagai Y. Anti-HIV-1 and chemotactic activities of human SDF-1 alpha and SDF-1 beta are abolished by CD26/dipeptidyl peptidase IV mediated cleavage. Proc Natl Acad Sci U S A. 1998;95:6331-6336.
  2. Fujii T, Taguchi H, Katano H, Mori S, Nakamura T, Nojiri N, Nakajima K, Tadokoro K, Juji T, and Iwamoto A. Seroprevalence of HHV8 in HIV-1 positive and negative populations in Japan. J Med Virol. 1999;57:159-162.
  3. Liu H, Chao D, Nakayama EE, Taguchi H, Gotoh M, Xin X, Takamatsu J, Saito H, Ishikawa Y, Akaza T, Juji T, Takebe Y, Ohishi T, Fukutake K, Maruyama Y, Yashiki S, Sonoda S, Nakamura T, Nagai Y, Iwamoto A, Shioda T. Polymorphism in RANTES chemokine promoter affects HIV-1 disease progression. Proc Natl Acad Sci U S A. 1999;96:4581-4585.
  4. Yamada T and Iwamoto A. Expression of a novel Nef epitope on the surface of HIV-1 infected cells. AIDS Res Hum Retroviruses. 1999;15:1001-1009.
  5. Kawana A, Tomiyama H, Takiguchi M, Shioda T, Nakamura T, Iwamoto A. Accumulation of specific amino acid substitutions in HLA-B35-restricted human immunodeficiency virus type-1 cytotoxic T lymphocyte epitopes. AIDS Res Hum Retroviruses. 1999;15:1099-1107.
  6. Nakayama EE, Hoshino Y, Xin X, Liu H, Goto M. Watanabe N, Taguchi H, Hitani A, Kawana-Tachikawa A, Fukushima M, Yamada K, Sugiura W, Oka S, Sato H, TakebeY, Ajisawa A, Nakamura T, Nagai Y, Iwamoto A, Shida T. Polymorphism in the IL-4 promoter affects acquisition of HIV-1 syncytium inducing (SI) phenotype. J Virol. 2000;74:5452-5459.
  7. Takahashi T, Hosoya N, Endo T, Nakamura T, Sakashita H, Kimura K, Ohnishi K, Nakamura Y, Iwamoto A. Relationship between mutations in dihydropteroate synthase of Pneumocystis carinii f. sp. hominis isolates in Japan and resistance to sulfonamide therapy. J Clin Microbiol. 2000;38:3161-3164.
  8. Koibuchi T, Hitani A, Nakamura T, Nojiri N, Nakajima K, Jyuji T, Iwamoto A. Predominance of genotype A HBV in HBV-HIV-1 dually positive population as compared to HIV-1-negative counterpart in Japan. J Med Virol. 2001:64:435-440.
  9. Watanabe N, Tomizawa M, Tachikawa-Kawana A, Goto M, Ajisawa A, Nakamura T, Iwamoto A. Quantitative and qualitative abnormalities in HIV-1-specific T cells. AIDS. 2001;15:711-715.
  10. Kawana-Tachikawa A, Tomizawa M, Nunoya J, Shioda T, Kato A, Nakayama EE, Nakamura T, Nagai Y, Iwamoto A. An effective and versatile mammalian viral vector system for MHC class I/peptide complexes. J Virol. 2002;76;11982-11988.