Physician Education: Bridging Clinical Research and Patient Care

Faculty Profile

MetroHealth Medical Center
Associate Professor
Case Western Reserve University
Cleveland, OH

Topics of Professional Interest:
  • Antiretrovirals and hepatitis C virus (HCV) infection
  • Predicting HCV response to interferon alfa therapy
  • HIV and HCV and hepatitis B virus (HBV) coinfections
  • New therapies for HCV infections
Current Professional Summary:

Dr Osborn is an Associate Professor at Case Western Reserve University in Cleveland, Ohio.  She specializes in HIV and viral hepatitis coinfection, and provides clinical care for HIV monoinfected patients and general infectious diseases patients.  In addition to clinical duties, she completed a Masters of Science in Clinical Research.  She recently joined the Infectious Disaese faculty at MetroHealth Medical Center in Cleveland where she will be establishing an HIV/HCV coinfection clinic, as well as working with the gastroenterology division in caring for HCV monoinfected patients, both in standard of care and as part of a clinical trials program. 

Committees and Organizations:
  • Member, American Gastroenterological Association
  • Member, Infectious Diseases Society of America/HIV Medicine Association
  • Member, American Association for the Study of Liver Diseases
Honors and Awards:
  • Jonas Shulman Teacher of the Year Award, Emory Division of Infectios Diseases (2009)
  • Emory University School of Medicine Fellow's Teaching Award (2004-2005)
  • Conference on Retroviruses and Opportunistic Infections Young Investigator Award (2006)
  • BS in Biology, Mount Union College (1995)
  • MD in Medicine, Ohio State University (1999)
  • MS in Clinical Research, Emory University, (2008)
  • Residency in Internal Medicine, Emory University School of Medicine (1999-2002)
  • Fellowship in Infectious Diseases, Emory University School of Medicine (2003-2006)
Selected Publications:

1.  Osborn MK, Lok ASF. Antiviral options for the treatment of chronic hepatitis B. Journal of Antimicrobial Chemotherapy. 2006; 57:1030-34


2.  Osborn MK, Guest JL, Rimland D.  Hepatitis B and HIV coinfection: relationship of different serologic patterns to survival and liver disease. HIV Medicine 2007; 8:271-279.


3.  Osborn MK, Regev A, Han S, Bzowej N, Ishitani M, Tran T, Lok ASF.  Outcomes of patients with hepatitis B who develop viral breakthrough or genotypic resistance to antiviral therapy while on the liver transplant waiting list  Clinical Gastroenterology and Hepatology 2007; 5(12): 1454-61.

4.  Osborn MK, Steinberg JP.  Subdural empyema and other suppurative complications of paranasal sinusitis.  The Lancet Infectious Diseases. 2007; 7:62-87.


5.  Hidron AI, Scheutz AN, Nolte FS, Gould CV, Osborn MK.  Daptomycin resistance in Enterococcus faecalis prosthetic valve endocarditis.  Journal of Antimicrobial Chemotherapy 2008; 61(6):1394-5.


6.  Radziewicz H, Ibegbu CC, Hon H, Osborn MK, Obideen K, Wehbi M, Freeman GJ, Lennox JL, Workowski KA, Hanson HL, Grakoui A. Impaired HCV specific effector CD8+ T cells undergo massive apoptosis in the peripheral blood during acute HCV infection and in the liver during the chronic phase of infection.  Journal of Virology.  2008; 82(20): 9808-22.


7.  Osborn MK. Hepatitis B in HIV: Available Treatment Options and Approach to Therapy.  Current Infectious Disease Reports 2009; 11: 407-413.


8.  Osborn MK. Safety and efficacy of telbivudine in the treatment of chronic hepatitis B.  Invited review Therapeutics and Clinical Risk Management 2009; 5: 789-798.


9.  Dionne-Odom J, Osborn MK, Radziewicz H, Workowski K.  Acute hepatitis C and HIV coinfection.  The Lancet Infectious Diseases 2009; 9: 775-83.


10.  Anderson AM, Mosunjac MB, Palmore MP, Osborn MK, Muir AJ.  Development of fatal acute liver failure in HIV-HBV coinfected patients.  World Journal of Gastroenterology.  2010; 16 (32): 4107-4111.


11.  Osborn, M.  Safety and efficacy of entecavir for the treatment of hepatitis B.  Infection and Drug Resistance; 2011; 4: 55-64.


12.  Kuppalli K, Doshi R, Armstrong W, Osborn M, Gunthel C.  Male with fungating skin lesions. Infectious Disease Clinical Practice; 2011; 19(4): 279-81.


13.  Miller L. Fluker S. Osborn M. Liu X. Strawder A.  Improving access to hepatitis C care for urban, underserved patients using a primary-care based hepatitis c clinic.  Journal of the National Medical Association 2012; (in press)


14.  Kuppalli K, Livorsi D, Talati N, Osborn M.  Lemierre’s syndrome due to Fusobacterium necrophorum.  Lancet Infectious Diseases. (e-published ahead of print 5-24-2012)



Management of Hepatitis C Virus in the New Era: Small Molecules Bring Big Changes