Physician Education: Bridging Clinical Research and Patient Care

Faculty Profile

Distinguished Professor of Pediatrics
Chief, Division of Infectious Diseases
Director, Mother-Child-Adolescent HIV Program
University of California San Diego
La Jolla, CA

Topics of Professional Interest:
  • HIV pathogenesis
  • Pediatric HIV and mother-to-child transmission
  • Host genetics and pharmacogenetics
  • Vitamin D and HIV
Current Professional Summary:

Dr Spector is Distinguished Professor of Pediatrics, Chief of the Division of Infectious Diseases, and Director of the Mother-Child-Adolescent HIV Program at the University of California San Diego and Rady Children’s Hospital. His laboratory focuses on HIV pathogenesis and host-virus interactions with an emphasis on specific genetic variants that are associated with HIV disease progression, mother-to-child transmission, and antiretroviral pharmacogenetics.

Committees and Organizations:
  • Chair, Executive Committee, Pediatric AIDS Clinical Trials Group (PACTG) (1996-2006)
  • Member, Network Executive Committee IMPAACT Network
  • Member, Scientific Leadership Group Pediatric HIV/AIDS Cohort Study (PHACS)
  • Member, Department of Health and Human Services HIV Perinatal Working Group
  • Senior Advisor, President’s Emergency Fund for AIDS Relief (PEPFAR)
Honors and Awards:
  • Children’s Hospital of Philadelphia, Herman and Gertrude Silver Award for work on behalf of children, adolescents and families affected by HIV disease (2010)
  • Rady Children’s Hospital San Diego Research Award (2010)
  • Elected to American Association of Physicians (2009)
  • Honored by Pediatric AIDS Clinical Trials Group for exceptional contributions and leadership (2006)
  • Honored by South African Embassy to the United States for contributions helping to prevent and treat HIV infection of children (2005)
  • State University of New York, BA (High Honors) (1971)
  • Tufts University School of Medicine, MD (1975)
Selected Publications:
  1. Zhou D, Masliah E, Spector SA. Autophagy is increased in postmortem brains of persons with human immunodeficiency virus type-1 associated encephalitis. J Infect Dis. 2011;(In press).
  2. Spector SA. Vitamin D earns more than a passing grade. J Infect Dis. 2009;200:1015-1017.
  3. Singh KK, Spector SA. Host genetic determinants of human immunodeficiency virus infection and disease progression in children. Pediatr Res. 2009;65:55R-63R.
  4. Zhou D, Spector SA. Human immunodeficiency virus type-1 infection inhibits autophagy. AIDS. 2008;22:695-699.
  5. Saitoh A, Fletcher CV, Brundage R, et al. Efavirenz pharmacokinetics in HIV-1-infected children are associated with CYP2B6-G516T polymorphism. JAIDS. 2007;45:280-285.
  6. Singh KK, Hughes MD, Chen J, Spector SA. Genetic polymorphisms in CX3CR1 predict HIV-1 disease progression in children independently of CD4+ lymphocyte count and HIV-1 RNA load. J Infect Dis. 2005;191:1971-1980.
  7. Saitoh A, Hsia K, Fenton T, et al. Persistence of human immunodeficiency virus (HIV) type 1 DNA in peripheral blood despite prolonged suppression of plasma HIV-1 RNA in children. J Infect Dis. 2002;185:1409-1416.
  8. Spector SA, Wong R, Hsia K, Pilcher M, Stempien MJ. Plasma cytomegalovirus (CMV) DNA load predicts CMV disease and survival in AIDS patients. J Clin Invest. 1998;101:497-502.
  9. Spector SA, McKinley GF, Lalezari JP, et al. Oral ganciclovir for the prevention of cytomegalovirus disease in persons with AIDS. Roche Cooperative Oral Ganciclovir Study Group. N Engl J Med. 1996;334:1491-1497.
  10. Hsia K, Spector SA. Human immunodeficiency virus DNA is present in a high percentage of CD4+ lymphocytes of seropositive individuals. J Infect Dis. 1991;164:470-475.