Physician Education: Bridging Clinical Research and Patient Care

Faculty Profile

Chief, Immunology Laboratory
Vaccine Research Center
National Institutes of Health
Bethesda, MD

Topics of Professional Interest:
  • Cellular immunity to HIV
  • HIV vaccine development
  • Immune response and reconstitution after highly active antiretroviral therapy for HIV infection
  • Immunotherapeutic strategies in HIV infection
Current Professional Summary:

Dr Koup is Chief of the Immunology Laboratory at the NIH Vaccine Research Center in Bethesda. He was previously Chief of Infectious Diseases, Professor of Medicine and Microbiology, and the Jay P. Sanford Professor of Infectious Diseases at the University of Texas Southwestern Medical Center in Dallas. Dr Koup has been actively involved in HIV vaccine-related research, where his studies have focused on the role of HIV-specific cellular immunity in controlling HIV infection. He serves on the editorial board of Journal of Infectious Diseases and is an editor of Journal of Virology and AIDS Research and Human Retroviruses.

Committees and Organizations:
  • Fellow, Infectious Diseases Society of America
  • Member, American Society for Clinical Investigation
  • Member, Association of American Physicians
Honors and Awards:
  • Max Finland Research Award, Massachusetts Infectious Disease Society (1988)
  • Scholar of the Pediatric AIDS Foundation (1989–1992)
  • Elizabeth Glaser Scientist of the Pediatric AIDS Foundation (1996–2000)
  • University of Connecticut, BS in Biophysics (1978)
  • University of Connecticut, MS in Biochemistry (1979)
  • The Johns Hopkins University School of Medicine, MD (1982)
  • Rhode Island Hospital, Residency in Internal Medicine (1982–1985)
  • University of Massachusetts Medical Center, Fellowship in Infectious Disease (1985–1987)
Selected Publications:
  1. Koup RA, Safrit JT, Cao Y, Andrews CA, McLeod G, Borkowsky W, Farthing C, Ho DD. Temporal association of cellular immune responses with the initial control of viremia in primary HIV-1 syndrome. J Virol. 1994;68:4650-4655.
  2. Wolinsky SM, Korber BTM, Neumann A, Daniels M, Kuntsman KJ, Whetsell AJ, Cao Y, Ho DD, Safrit JT, Koup RA. Adaptive evolution of human immunodeficiency virus type 1 during the natural course of infection. Science.1996;272:537-542.
  3. Douek DC, McFarland RD, Keiser PH, Gage EA, Massey JM, Haynes BF, Polis MA, Haase AT, Feinberg MB, Sullivan JL, Jamieson BD, Zack JA, Picker LJ, Koup RA. Changes in thymic function with age and during the treatment of HIV infection. Nature. 1998;396:690-695.
  4. Pitcher CJ, Quittner C, Peterson DM, Connors M, Koup RA, Maino VC, Picker LJ. HIV-1 specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression. Nat Med. 1999;5:518-525.
  5. Jamieson BD, Douek DC, Killian S, Hultin LE, Scripture-Adams DD, Giorgi JV, Marelli D, Koup RA, Zack JA. Generation of functional thymocytes in the human adult. Immunity. 1999;10:569-575.
  6. Little SJ, Daar ES, D'Aquila RT, Keiser PH, Connick E, Whitcomb JM, Hellman NS, Petropoulos CJ, Sutton L, Pitt JA, Rosenberg ES, Koup RA, Walker BD, Richman DD. Reduced antiretroviral drug susceptibility among patients with primary HIV infection. JAMA.1999;282:1142-1149.
  7. McFarland RD, Douek DC, Koup RA, Picker LJ. Identification of a human recent thymic emigrant phenotype. Proc Natl Acad Sci USA.2000;97:4215-4220.
  8. Douek DC, Brenchley JM, Betts MR, Ambrozak DR, Hill BJ, Okamoto Y, Casazza JP, Kuruppu J, Kunstman K, Wolinsky S, Grossman Z, Dybul M, Oxenius A, Price DA, Connors M, Koup RA. HIV preferentially infects HIV-specific CD4+ T cells. Nature. 2002;417:95-89.
  9. Betts MR, Price DA, Brenchley JM, Lore K, Guenaga FJ, Smed-Sorensen A, Ambrozak DR, Migueles SA, Connors M, Roederer M, Douek DC, Koup RA. The functional profile of primary human antiviral CD8+ T cell effector activity is dictated by cognate peptide concentration. J Immunol. 2004;172:6407-6417.