Paul E. Sax, MD

A. The meningococcal type B (4CMenB) vaccine significantly reduced the rate of gonorrhea infections among men who have sex with men (MSM)

B. Despite an increase in sexual risk among MSM and transgender women newly starting doxycycline postexposure prophylaxis (doxy-PEP), bacterial STI rates fell by approximately half in the Evaluation of Doxycycline Post-exposure Prophylaxis to Reduce Sexually Transmitted Infections in PrEP Users and HIV-infected Men Who Have Sex With Men study

C. Doxycycline was present in the majority of hair samples collected among women in the dPEP-KE (Doxycycline PEP for Prevention of Sexually Transmitted Infections Among Kenyan Women Using HIV PrEP) study, suggesting that biologic factors explain the lack of doxy-PEP efficacy in women

D. In the year after the implementation of doxy-PEP guidelines in San Francisco, rates of chlamydia, syphilis, and gonorrhea in MSM and transgender women fell by half

Paul E. Sax, MD

Paul E. Sax, MD

Harvard Medical School

April 22, 2024: Prevention of Bacterial Sexually Transmitted Infections