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Practice Question of the Week

Which of the following statements about long-acting injectable cabotegravir (CAB-LA) for HIV preexposure prophylaxis is TRUE?
- A. CAB-LA is less effective in the setting of active bacterial sexually transmitted infections
- B. Every 2-month thigh injections of CAB-LA resulted in similar pharmacokinetics to every 2-month gluteal injections
- C. During CAB-LA follow-up, the combination of a rapid HIV test and antigen/antibody test or 2 rapid tests that give the same result (eg, both positive or both negative) had high positive and negative predictive values
- D. Integrase strand transfer inhibitor resistance mutations are unlikely to emerge in the setting of breakthrough infections with CAB-LA