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David H. Spach, MD
David H. Spach, MD
Professor of Medicine
University of Washington
Seattle, WA
CROI
Conference on Bacteriophages
RWHAP CLINICAL CONFERENCE
Podcasts
Slides
Question of the Week
Guidelines
Contact
CME Courses
HIV In-Person and Virtual Courses
Current On-Demand Courses
About Courses
CME Webinars
Upcoming Webinars
Current On-Demand Webinars
MATE Act CME
About Webinars
Dialogues
Upcoming IAS–USA Dialogues: Emerging Infections and Health Threats
On-Demand Dialogues
About Dialogues
Topics In Antiviral Medicine
Current Issues for CME
Previous Issues
TAM
Policies and Practices
Permission Request Form
HIV Drug Resistance
HIV Drug Resistance Resources
HIV Drug Resistance Mutations Chart
Recent Webinars
Journal Articles
Fellow Resources
Resources for Fellows and Others New to the HIV Field
On-Demand Webinars for Fellows
IAS-USA Guidelines and Recommendations
On-Demand Webcasts
Research Collaborations
Additional Resources
About
Scientific Leadership Board
IAS-USA Leadership Award Recipients
Core Faculty
Mission
Staff
CME
Funding Information
Careers
Website Policies
Discrimination and Harassment Policy
Governance
Suggestions and Recommendations from San Francisco Locals
Donate
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Practice Question of the Week
November 9, 2026: Hepatitis B Immunization Strategies in People With HIV
A 43-year-old woman establishes care for HIV infection. Screening for hepatitis B virus (HBV) reveals positive hepatitis B core antibody (HBcAb), negative hepatitis B surface antigen (HBsAg), and negative hepatitis B surface antibody (HBsAb) test results. Regarding hepatitis B vaccination, which of the following is the best next step in management?
A. Administer 2 doses of the adjuvanted hepatitis B vaccine (Heplisav-B) followed by a test for immunity in 1 month
B. Administer 3 doses of the double-dose recombinant hepatitis B vaccine, followed by a test for immunity in 1 month
C. Administer a single dose of the hepatitis B vaccine, followed by a test for immunity in 1 month
D. Check HBV DNA level before determining the need for vaccination
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