Donna E. Sweet, MD

A. ARTISTRY-1 included people who were treatment naive without underlying HIV drug resistance

B. ARTISTRY-1 excluded those with any integrase strand transfer inhibitor (InSTI) resistance mutations

C. ARTISTRY-1 demonstrated that BIC/LEN is the best studied switch option for those who are virologically suppressed with highly nRTI-resistant virus

D. ARTISTRY-1 demonstrated that this patient would be less likely to remain suppressed if switched to a second-generation InSTI + FTC/TAF than if switched to BIC/LEN

Donna E. Sweet, MD

Donna E. Sweet, MD

Professor of Internal Medicine

University of Kansas

Lawrence, KS

October 12, 2026: Simplifying Antiretroviral Regimens in Virologically Suppressed Patients With Drug Resistance