Elaine J. Abrams, MD

A. They have been commonly used for decades, with more than 100 trials conducted pre-COVID-19

B. They are larger than a combination of individually randomized clinical trials (RCTs) answering the same questions.

D. Sites may have the option to include or exclude participants for each treatment based on product availability

E. To maintain the blinding, only agents with the same mode of administration (eg, oral, intravenous) can be combined into a single platform trial