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Huldrych F. Günthard, MD

Huldrych F. Günthard, MD

Professor of Infectious Diseases

University Hospital Zurich

Zurich, Switzerland

Senior Staff Physician
Institute of Medical Virology

131 Steuart St, Suite 500, San Francisco, CA 94105

Phone: (415) 544-9400 | info@iasusa.org

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CROI
Conference on Bacteriophages
RWHAP CLINICAL CONFERENCE
Podcasts
Slides
Question of the Week
Guidelines
Contact
CME Courses
CME Webinars
Dialogues
Topics In Antiviral Medicine
HIV Drug Resistance
Fellow Resources
About

Practice Question of the Week

November 9, 2026: Hepatitis B Immunization Strategies in People With HIV

A 43-year-old woman establishes care for HIV infection. Screening for hepatitis B virus (HBV) reveals positive hepatitis B core antibody (HBcAb), negative hepatitis B surface antigen (HBsAg), and negative hepatitis B surface antibody (HBsAb) test results. Regarding hepatitis B vaccination, which of the following is the best next step in management?

A. Administer 2 doses of the adjuvanted hepatitis B vaccine (Heplisav-B) followed by a test for immunity in 1 month

B. Administer 3 doses of the double-dose recombinant hepatitis B vaccine, followed by a test for immunity in 1 month

C. Administer a single dose of the hepatitis B vaccine, followed by a test for immunity in 1 month

D. Check HBV DNA level before determining the need for vaccination

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