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Jason E. Zucker, MD
Jason E. Zucker, MD
Assistant Professor of Medicine
Columbia University
New York, NY
CROI
Conference on Bacteriophages
RWHAP Clinical Conference
Podcasts
Slides
Question of the Week
Donate
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CME Courses
HIV In-Person and Virtual Courses
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MATE Act CME
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Dialogues
Upcoming IAS–USA Dialogues
On-Demand Dialogues
About Dialogues
Topics In Antiviral Medicine
Current Issues for CME
Previous Issues
TAM
Policies and Practices
Permission Request Form
HIV Drug Resistance
Drug Resistance Mutations Chart
Recent Webinars
Journal Articles
Fellow Resources
Fellow Resources
IAS-USA Guidelines and Recommendations
On-Demand Webcasts
Research Collaborations
Additional Resources
About
Scientific Leadership Board
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Practice Question of the Week
June 16, 2025: Current Treatment Options for Syphilis
A 32-year-old man presents to care with a single, painless ulcer on the ventral shaft of the penis. He does not have a prior rapid plasma reagin (RPR) test result, and he reports recent condomless sex with a new partner. Which of the following is the most appropriate treatment?
A. Benzathine penicillin G 2.4 million units intramuscularly (IM) in a single dose
B. Doxycycline 100 mg orally twice daily for 7 days
C. Benzathine penicillin G 2.4 million units IM weekly for 3 weeks
D. Wait for RPR test results before initiating any treatment
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