Jeanne M. Marrazzo, MD, MPH

A. Start LAI ART in people with HIV (PWH) with detectable viremia if clinic attendance is expected to be high

B. Initiate LAI ART in PWH who are virologically suppressed on oral ART, who do not have known resistance to regimen components, and who have a plan for missed doses

C. Avoid LAI ART in PWH with prior ART failure, even if currently virologically suppressed

D. Require an oral lead-in for PWH to reduce injection reactions and prevent treatment failure

Jeanne M. Marrazzo, MD, MPH

Jeanne M. Marrazzo, MD, MPH

Director, on Administrative Leave

National Institutes of Allergy and Infectious Diseases

Bethesda, MD

March 10, 2026: Optimization of Long-Acting Injectable Antiretroviral Therapy