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Jennifer W. Janelle, MD
Jennifer W. Janelle, MD
University of Florida
Gainesville, FL
CROI
Conference on Bacteriophages
RWHAP Clinical Conference
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Question of the Week
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Upcoming IAS–USA Dialogues
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Topics In Antiviral Medicine
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TAM
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HIV Drug Resistance
Drug Resistance Mutations Chart
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IAS-USA Guidelines and Recommendations
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Practice Question of the Week
June 16, 2025: Current Treatment Options for Syphilis
A 32-year-old man presents to care with a single, painless ulcer on the ventral shaft of the penis. He does not have a prior rapid plasma reagin (RPR) test result, and he reports recent condomless sex with a new partner. Which of the following is the most appropriate treatment?
A. Benzathine penicillin G 2.4 million units intramuscularly (IM) in a single dose
B. Doxycycline 100 mg orally twice daily for 7 days
C. Benzathine penicillin G 2.4 million units IM weekly for 3 weeks
D. Wait for RPR test results before initiating any treatment
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