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Jessica Merlin, MD, PhD, MBA

Jessica Merlin, MD, PhD, MBA

Professor of Medicine with Tenure

University of Pittsburgh

Pittsburgh, PA

131 Steuart St, Suite 500, San Francisco, CA 94105

Phone: (415) 544-9400 | info@iasusa.org

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CROI
Conference on Bacteriophages
RWHAP Clinical Conference
Podcasts
Slides
Question of the Week
Donate
Contact
CME Courses
CME Webinars
Dialogues
Topics In Antiviral Medicine
HIV Drug Resistance
Fellow Resources
About

Practice Question of the Week

June 16, 2025: Current Treatment Options for Syphilis

A 32-year-old man presents to care with a single, painless ulcer on the ventral shaft of the penis. He does not have a prior rapid plasma reagin (RPR) test result, and he reports recent condomless sex with a new partner. Which of the following is the most appropriate treatment?
- A. Benzathine penicillin G 2.4 million units intramuscularly (IM) in a single dose
- B. Doxycycline 100 mg orally twice daily for 7 days
- C. Benzathine penicillin G 2.4 million units IM weekly for 3 weeks
- D. Wait for RPR test results before initiating any treatment

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