Joseph Bondy-Denomy, PhD

Dr Bondy-Denomy is a Professor in the Department of Microbiology & Immunology at the University of California San Francisco (UCSF). Prior to coming to UCSF, Dr Bondy-Denomy was a PhD student with Alan Davidson at the University of Toronto and received his undergraduate degree in Biology from the University of Waterloo. His lab is focused on studying the interactions between bacteriophages and the defense systems encoded by host bacteria, specifically focused on the human pathogen Pseudomonas aeruginosa. Historically, the lab has studied clustered regularly interspaced short palindromic repeats (CRISPR)-Cas systems and their inhibitors, anti-CRISPR proteins. More recent work has broadened that interest to include unique mechanisms of CRISPR-Cas evasion, such as “phage nucleus” compartments. The lab has also begun to characterize the immunity and anti-immunity mechanisms of Gabija, cyclic-oligonucleotide-based anti-phage signaling system (CBASS), Thoeris, Shango, and Jumbo phage killer defenses. Work in the Bondy-Denomy lab has been funded by the National Institutes of Health (NIH), Defense Advanced Research Projects Agency (DARPA), the Searle Scholars Program, the Vallee Foundation, and the Innovative Genomics Institute. Dr Bondy-Denomy serves as a reviewer for the NIH and other granting agencies and for many journals. He is also the cofounder of Acrigen Biosciences, a gene editing company using anti-CRISPR proteins, and on the scientific advisory board of SNIPR Biome, Leapfrog Bio, and Excision Biotherapeutics.

(Updated July 18, 2024)