Marina Klein, MD, MS

A. Start LAI ART in people with HIV (PWH) with detectable viremia if clinic attendance is expected to be high

B. Initiate LAI ART in PWH who are virologically suppressed on oral ART, who do not have known resistance to regimen components, and who have a plan for missed doses

C. Avoid LAI ART in PWH with prior ART failure, even if currently virologically suppressed

D. Require an oral lead-in for PWH to reduce injection reactions and prevent treatment failure

Marina Klein, MD, MS

Marina Klein, MD, MS

Professor of Medicine

McGill University

Montreal, QC, Canada

March 10, 2026: Optimization of Long-Acting Injectable Antiretroviral Therapy