Michael T. Laub, PhD
Salvador E. Luria Professor of Biology
Massachusetts Institute of Technology
Cambridge, MA
Dr Laub’s research currently focuses on phage-bacteria interactions with a particular emphasis on the antiphage defense mechanisms used by bacteria to defend themselves against phages and the counterdefense mechanisms employed by phages. We use a variety of genetic and computational tools to identify new antiphage defense systems in E. coli, B. subtilis, and S. aureus. The mechanistic basis of immunity provided by individual systems is pursued using a combination of genetics, biochemistry, cell biology, and structural approaches. The lab also examines the tempo, modes, and patterns of genome evolution in bacteria and phages that stems from their constant battle with each other.
(Updated July 18, 2024)