R. Douglas Bruce, MD, MA, MS

A. Nirmatrelvir is highly protein bound

B. The protein-adjusted 90% effective concentration (EC90) for nirmatrelvir is 292 ng/mL

C. Race, weight, and renal function influence nirmatrelvir PK

D. In the EPIC-SR (Evaluation of Protease Inhibition for COVID-19 in Standard-Risk Patients) and EPIC-HR (Evaluation of Protease Inhibition for COVID-19 in High-Risk Patients) trials in persons with COVID-19, those with a nirmatrelvir trough above 1000 ng/mL had faster time to symptom resolution

R. Douglas Bruce, MD, MA, MS

R. Douglas Bruce, MD, MA, MS

Boston University

June 27, 2022: Pharmacokinetics (PK) and PK-Pharmacodynamics (PD) of Nirmatrelvir/Ritonavir