Serena S. Spudich, MD

Serena S. Spudich, MD

Yale University School of Medicine

Professor of Neurology
Yale University School of Medicine
New Haven, Connecticut


Committees and Organizations

  • Panel Member, USA HHS Panel on Antiretroviral Guidelines for Adults and Adolescents
  • Program Committee Member, Conference on Retroviruses and Opportunistic Infections
  • Chair Ex-officio, Neurology Collaborative Science Group, AIDS Clinical Trials Group
  • Previously Investigator-at-large, AIDS Clinical Trials Group (ACTG) HIV Reservoirs and Eradication Transformative Science Group

Honors and Awards

  • 2004 Young Investigator Award, 11th Conference on Retroviruses and Opportunistic Infections
  • 2003 Warren-Whitman Richardson Fellowship, Harvard Medical School
  • 2002 John P. Utz Fellowship in Medical Mycology, National Foundation for Infectious Diseases
  • 2002 Clinical Investigator Training Program Fellowship, Harvard University/Massachusetts Institute of Technology, Division of Health, Sciences, and Technology
  • 1999 Huesby Award for Teaching, Department of Medicine, University of Washington


  • Stanford University, B.A. in Human Biology with Honors in Humanities (1991)
  • Stanford University, M.A. in Philosophy of Science (1992)
  • University of California, San Francisco, MD with Thesis (1997)
  • University of Washington, Seattle, Internal Medicine Resident (1997-99)
  • Massachusetts General/Brigham and Women’s Hospital (Harvard), Neurology Resident (1999-2002)
  • Harvard Medical School, Neuro-infectious Disease Fellowship (2003)
  • University of California, San Francisco, Neuro-AIDS Fellowship (2004)

Selected Publications

  1. Spudich SS, Huang W, Nilsson AC, Petropoulos CJ, Liegler TJ, Whitcomb JM, Price RW. HIV-1 Chemokine Coreceptor Utilization in Paired Cerebrospinal Fluid and Plasma Samples: A Survey of Subjects with Viremia. Journal of Infectious Diseases, 2005; 191:890-8.
  2. Spudich S, Nilsson A, Liegler T, Petropoulos C, Deeks SG, Paxinos EE, Price RW. Cerebrospinal Fluid HIV Infection and Pleocytosis: Relation to Systemic Infection and Antiretroviral Treatment. Biomed Central Infectious Diseases, 2005; 5(98).
  3. Spudich S, Lollo N, Liegler T, Deeks SG, Price RW. Cerebrospinal Fluid HIV Treatment Benefit in the Setting of Systemic Virological Supression and Failure. Journal of Infectious Diseases. 2006 Dec 15;194(12):1686-96.
  4. Price, RW, Spudich S. Antiretroviral Therapy and Central Nervous System HIV-1 Infection. Journal of Infectious Diseases. 197 Suppl 3:S294-306, 2008.
  5. Probasco J, Deeks SG, Lee E, Hoh R, Price RW, Spudich S. Cerebrospinal Fluid in HIV-1 Systemic Viral Controllers: Absence of HIV-1 RNA and Intrathecal Inflammation. AIDS, 2010 Apr 24;24(7):1001-5.
  6. Schnell G, Price RW, Swanstrom R, and Spudich S. Compartmentalization and Clonal Amplification of HIV-1 Variants in the Cerebrospinal Fluid during Primary Infection. Journal of Virology, 2009 Dec 16.
  7. Edén A, Fuchs D, Hagberg L, Nilsson S, Spudich S, Svennerholm B, Price RW, Gisslén M. HIV-1 viral escape in cerebrospinal fluid of subjects on suppressive antiretroviral treatment. Journal of Infectious Diseases, 2010 Dec 15;202(12):1819-25.
  8. Spudich S, GisslenM, HagbergL, LeeE, LieglerT, BrewB, FuchsD, TambussiG, CinqueP, HechtFM, and Price RW. Central Nervous System Immune Activation Characterizes Primary HIV-1 Infection Even in Subjects with Minimal Cerebrospinal Fluid Viral Burden. Journal of Infectious Diseases, 2011; 204(5):753-60.
  9. Schnell G, Joseph S, Spudich S, Price RW, and Swanstrom R. HIV-1 Replication in the Central Nervous System Occurs in Two Distinct Cell Types. PloS Pathogens, 2011 Oct;7(10):e1002286.
  10. Valcour V, Chalermchai T, Sailasuta N, Marovich M, Lerdlum S, Suttichom D, Suwanwela N, Jagodzinski L, Michael N, Spudich S, Griensven F, de Souza M, Kim J, Ananworanich J, RV254/SEARCH 010 Study Group. CNS viral invasion and inflammation during acute HIV. Journal of Infectious Diseases, 2012 Jul;206(2):275-282.
  11. Peluso M, Ferretti F, Peterson J, Lee E, Fuchs D, Boschini A, Gisslen M, Angoff N, Price RW, Cinque P, and Spudich S. Symptomatic cerebrospinal fluid HIV escape in patients on antiretroviral therapy with suppressed plasma viral load. AIDS, 2012 May 17. [Epub ahead of print].