Serena S. Spudich, MD

Serena S. Spudich, MD

Yale University School of Medicine

Professor of Neurology
Yale University School of Medicine
New Haven, Connecticut


Committees and Organizations

  • Panel Member, USA HHS Panel on Antiretroviral Guidelines for Adults and Adolescents
  • Program Committee Member, Conference on Retroviruses and Opportunistic Infections
  • Investigator, Neurology Collaborative Science Group, AIDS Clinical Trials Group
  • Investigator, AIDS Clinical Trials Group (ACTG) HIV Reservoirs and Eradication Transformative Science Group

Honors and Awards

  • Gilbert H. Glaser Endowed Professor, Yale University
  • 2004 Young Investigator Award, 11th Conference on Retroviruses and Opportunistic Infections
  • 2003 Warren-Whitman Richardson Fellowship, Harvard Medical School
  • 2002 John P. Utz Fellowship in Medical Mycology, National Foundation for Infectious Diseases
  • 2002 Clinical Investigator Training Program Fellowship, Harvard University/Massachusetts Institute of Technology, Division of Health, Sciences, and Technology
  • 1999 Huesby Award for Teaching, Department of Medicine, University of Washington


  • Stanford University, B.A. in Human Biology with Honors in Humanities (1991)
  • Stanford University, M.A. in Philosophy of Science (1992)
  • University of California, San Francisco, MD with Thesis (1997)
  • University of Washington, Seattle, Internal Medicine Resident (1997-99)
  • Massachusetts General/Brigham and Women’s Hospital (Harvard), Neurology Resident (1999-2002)
  • Harvard Medical School, Neuro-infectious Disease Fellowship (2003)
  • University of California, San Francisco, Neuro-AIDS Fellowship (2004)

Selected Publications


1.    S Tovanabutra, R Sirijatuphat, PT Pham, et al,. . . S Spudich.  (2019) Deep Sequencing Reveals Central Nervous System      Compartmentalization in Multiple Transmitted/Founder Virus Acute HIV-1 Infection. Cells 8(8).

2.    S Spudich, KR Robertson, RJ Bosch, et al, . . . JW Mellors  (2019) Persistent HIV-infected cells in cerebrospinal fluid are associated with poorer neurocognitive performance. J Clin Invest 129(8):3339-3346.

3.    SF Farhadian, SS Mehta, C Zografou, et al, . . . S Spudich  (2018) Single-cell RNA sequencing reveals microglia-like cells in cerebrospinal fluid during virologically suppressed HIV. JCI Insight 3(18).

4.    R Sanford, B Ances, DJ Meyerhoff, et al, . . . S Spudich*, DL Collins*  (2018) Longitudinal Trajectories of Brain Volume and Cortical Thickness in Treated and Untreated Primary Human Immunodeficiency Virus Infection. Clin Infect Dis 67(11):1697-1704. *Co-senior

5.    E Rahimy, FY Li, L Hagberg, et al, . . . S Spudich  (2017) Blood-Brain Barrier Disruption Is Initiated During Primary HIV Infection and Not Rapidly Altered by Antiretroviral Therapy. J Infect Dis 215(7):1132-1140.

6.    CB Sturdevant, SB Joseph, G Schnell, RW Price, R Swanstrom, S Spudich  (2015) Compartmentalized replication of R5 T cell-tropic HIV-1 in the central nervous system early in the course of infection. PLoS Pathog 11(3):e1004720.

7.    AC Young, CT Yiannoutsos, M Hegde, et al, . . . S Spudich  (2014) Cerebral metabolite changes prior to and after antiretroviral therapy in primary HIV infection. Neurology 83(18):1592-1600.

8.    MJ Peluso, DJ Meyerhoff, RW Price, et al, . . . S Spudich  (2013) Cerebrospinal fluid and neuroimaging biomarker abnormalities suggest early neurological injury in a subset of individuals during primary HIV infection. J Infect Dis 207(11):1703-1712.

9.    MJ Peluso, F Ferretti, J Peterson, et al,. . . S Spudich  (2012) Cerebrospinal fluid HIV escape associated with progressive neurologic dysfunction in patients on antiretroviral therapy with well controlled plasma viral load. AIDS 26(14):1765-1774.

10.  S Spudich, M Gisslen, L Hagberg, et al, . . . RW Price  (2011) Central nervous system immune activation characterizes primary human immunodeficiency virus 1 infection even in participants with minimal cerebrospinal fluid viral burden. J Infect Dis 204(5):753-760.