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Topics in Antiviral Medicine
™
June 2025
Volume 33, Issue 3
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Selected Highlights of the 2025 Conference on Retroviruses and Opportunistic Infections
CROI 2025: Acute and Post-Acute COVID-19
Annukka A. R. Antar, MD, PhD, Michael J. Peluso, MD
CROI 2025: Metabolic and Other Complications of HIV Infection
Sudipa Sarkar, MD, Todd T. Brown, MD, PhD
CROI 2025: The Challenges of Sustaining Viral Suppression, Addressing Advanced HIV Disease, and Ending the HIV Epidemic Targets
Shauna H. Gunaratne, MD, MPH, Barbara S. Taylor, MD, MS, Timothy J. Wilkin, MD, MPH, Hong-Van Tieu, MD, MS
CROI 2025: Summary of Basic Science Research in HIV
Mario Stevenson, PhD
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CROI
Conference on Bacteriophages
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Upcoming IAS–USA Dialogues: Emerging Infections and Health Threats
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Practice Question of the Week
October 6, 2026: Drug-Drug Interactions With Antiretroviral Regimens
A 75-year-old person with HIV was no longer able to tolerate oral antiretroviral therapy and switched to lenacapavir (LEN) + cabotegravir (CAB) (intramuscular rilpivirine was not recommended due to the presence of nonnucleoside reverse transcriptase resistance mutations). Four weeks after the most recent injection, he had a cerebrovascular event. Clopidogrel was initiated by the neurologist. Which of the following best describes the risk of drug-drug interactions in this setting?
A. Both CAB and clopidogrel are UGT1A1 substrates, so levels of both agents may increase
B. LEN is a moderate CYP3A inducer and may increase plasma concentrations of clopidogrel
C. LEN is a moderate CYP3A inhibitor and may increase plasma concentrations of clopidogrel
D. Clopidogrel is a strong UGT1A1 inhibitor, and plasma levels of both LEN and CAB may increase
E. Drug interactions caused by LEN or CAB are only relevant around the maximum concentration (Cmax), which occurs 7 days after injection
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