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Topics in Antiviral Medicine
™
May 2025
Volume 33, Issue 2
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Special Contribution
2025 Update of the Drug Resistance Mutations in HIV-1
Annemarie M. Wensing, MD, PhD, Vincent Calvez, MD, PhD, Francesca Ceccherini-Silberstein, PhD, Charlotte Charpentier, PharmD, PhD, Huldrych F. Günthard, MD, Donna M. Jacobsen, BS, Roger Paredes, MD, PhD, Robert W. Shafer, MD, Douglas D. Richman, MD
Review
HIV and Liver Disease: Optimizing Care and Identifying the Gaps
Kenneth E. Sherman, MD, PhD, Phyllis C. Tien, MD, MSc, David L. Thomas, MD, MPH
Selected Highlights of the 2025 Conference on Retroviruses and Opportunistic Infections
CROI 2025: Neuropsychiatric Complications in People With HIV
Michael J. Corley, PhD, Phillip Chan, PhD, MBChB, Sarah B. Joseph, PhD
CROI 2025: Tuberculosis, Mpox, and Other Infectious Complications in People With HIV
Andrew D. Kerkhoff, MD, PhD, Jason Zucker, MD, Diane V. Havlir, MD
CROI 2025: Global Epidemiology and Prevention of HIV and Other Sexually Transmitted Diseases
Susan P. Buchbinder, MD, Albert Y. Liu, MD, MPH
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Practice Question of the Week
June 16, 2025: Current Treatment Options for Syphilis
A 32-year-old man presents to care with a single, painless ulcer on the ventral shaft of the penis. He does not have a prior rapid plasma reagin (RPR) test result, and he reports recent condomless sex with a new partner. Which of the following is the most appropriate treatment?
A. Benzathine penicillin G 2.4 million units intramuscularly (IM) in a single dose
B. Doxycycline 100 mg orally twice daily for 7 days
C. Benzathine penicillin G 2.4 million units IM weekly for 3 weeks
D. Wait for RPR test results before initiating any treatment
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