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Michael R. Charlton, MBBS
University of Chicago
Professor of Medicine
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Charlotte Charpentier, PharmD
University Paris Cité
Professor of Virology
Paris, France
Bichat-Claude Bernard Hospital
Paris, France
Cody A. Chastain, MD
Vanderbilt University Medical Center
Assistant Professor
Nashville, TN
Zoobia W. Chaudhry, MBBS
The John Hopkins University
Baltimore, MD
Laura W. Cheever, MD, ScM
HIV/AIDS Bureau, The Health Resources and Services Administration
Rockville, MD
Kara W. Chew, MD, MS
University of California Los Angeles
Associate Professor
Los Angeles, CA
Peter Chin-Hong, MD
University of California San Francisco
Professor of Medicine
San Francisco, CA
Nicolas Chomont, PhD
Université de Montréal–CHUM Research Center
Associate Professor
Montreal, QC, Canada
Carolyn Chu, MD, MSc
University of California San Francisco
San Francisco, CA
Kathleen A. Clanon, MD
Alameda Care Connect
Director
Oakland, CA
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CROI
Conference on Bacteriophages
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Practice Question of the Week
February 10, 2025: Multiple Comorbidities in People Living With HIV
A 68-year-old man who has sex with men was diagnosed with HIV 20 years ago. He is virologically suppressed on stable antiretroviral therapy. His CD4+ count is 640 cells/µL. His comorbidities include type 2 diabetes mellitus, hypertension, atherosclerotic cardiovascular disease with acute myocardial infarction 3 years ago, and prostate cancer. He leads a very sedentary lifestyle and has noticed increasing weakness and falls. Which of the following statements is correct?
A. A recent forecast indicates that by 2030, a quarter of people with HIV will be living with physical comorbidities
B. Recent data show that epigenetic aging significantly accelerates in people with HIV despite virologic suppression and immune recovery
C. Epigenetic age advancement is associated with greater mortality after adjusting for chronologic age
D. Survival gap between this patient and the general population is estimated to be 20 years or more
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